Lucio Miele

ORCID: 0000-0002-5853-7287 · 4 papers in corpus
2016
Aberrant activation of canonical Notch1 signaling in the mouse uterus decreases progesterone receptor by hypermethylation and leads to infertility.
Proceedings of the National Academy of Sciences of the United States of America ·doi:10.1073/pnas.1520441113

In mammalian reproduction, implantation is one of the most critical events. Failure of implantation and the subsequent decidualization contribute to more than 75% of pregnancy losses in women. Our laboratory has previously reported that inh…

2014
Assessing needs and assets for building a regional network infrastructure to reduce cancer related health disparities.
Evaluation and program planning ·doi:10.1016/j.evalprogplan.2013.12.003

Significant cancer health disparities exist in the United States and Puerto Rico. While numerous initiatives have been implemented to reduce cancer disparities, regional coordination of these efforts between institutions is often limited. T…

article 2014
Decreased Notch Pathway Signaling in the Endometrium of Women With Endometriosis Impairs Decidualization
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2014-3720

CONTEXT: Endometriosis is a common gynecological disease affecting one in 10 women of reproductive age and is a major cause of pelvic pain and impaired fertility. Endometrial stromal cells of women with endometriosis exhibit a reduced respo…

2012
Notch1 is regulated by chorionic gonadotropin and progesterone in endometrial stromal cells and modulates decidualization in primates.
Endocrinology ·doi:10.1210/en.2011-2122

No other tissue in the body undergoes such a vast and extensive growth and remodeling in a relatively short period of time as the primate endometrium. Endometrial integrity is coordinated by ovarian hormones, namely, estrogens, progesterone…