Kathrin Brüggemann

No ORCID on file · 3 papers in corpus · active 2013-2019

Study types

  • article 2
  • other 1

Condition tags

  • endometriosis 3
  • die_deep_infiltrating 1
article 2019
γ‐Secretase inhibition affects viability, apoptosis, and the stem cell phenotype of endometriotic cells
Acta obstetricia et gynecologica Scandinavica ·doi:10.1111/aogs.13707

INTRODUCTION: Stem cells mediate cyclic regeneration of the endometrium. The upregulated expression of receptors and modulators of the notch signaling pathway in endometriosis suggests an involvement in the pathogenetic process. Here, we in…

other 2013
MicroRNA miR-145 inhibits proliferation, invasiveness, and stem cell phenotype of an in vitro endometriosis model by targeting multiple cytoskeletal elements and pluripotency factors
Fertility and sterility ·doi:10.1016/j.fertnstert.2012.11.055

OBJECTIVE: To study the function of miR-145, known to be dysregulated in endometriosis, and to identify its target genes in an in vitro endometriosis model. DESIGN: Experimental laboratory study. SETTING: University medical centers. PATI…

article 2013
Pharmacological interference with the stemness-associated Notch-signaling pathway exerts an antiproliferative effect on the endometriotic 12Z cell line
·doi:10.1055/s-0033-1336720

Adult stem cells are thought to participate in endometrial regeneration during the reproductive phase of women. We have previously demonstrated dysregulated stem cell activity in endometriosis, a benign disease associated with unspecific pa…