Anthony H. Taylor

2020

(Endo)Cannabinoids and Gynaecological Cancers.

Cancers ·doi:10.3390/cancers13010037

Gynaecological cancers can be primary neoplasms, originating either from the reproductive tract or the products of conception, or secondary neoplasms, representative of metastatic disease. For some of these cancers, the exact causes are unk…

article 2013

Estradiol and tamoxifen enhance invasion of endometrial stromal cells in a three-dimensional coculture model of adenomyosis

Fertility and sterility ·doi:10.1016/j.fertnstert.2013.09.042

ObjectiveTo examine the effect of estradiol alone or with progesterone and tamoxifen on the depth of invasion of endometrial stromal cells from women with and without adenomyosis in a three-dimensional (3D) coculture model that includes myo…

article 2012

Raloxifene inhibits the expression of the endocannabinoid system in endometriotic lesions

·doi:10.1080/1062936x.2014.955055

A new graphical description of the primary structure of protein sequences is introduced. First, a three-dimensional space discrete point set of a protein sequence is created based on the three main physicochemical properties of the amino ac…

article 2011

Changes in glandular and stromal estrogen and progesterone receptor isoform expression in eutopic and ectopic endometrium following treatment with the levonorgestrel-releasing intrauterine system

European journal of obstetrics, gynecology, and reproductive biology ·doi:10.1016/j.ejogrb.2011.02.013

ObjectivesThe levonorgestrel (LNG) intrauterine system (LNG-IUS) has been shown to improve symptoms in women with minimal to moderate endometriosis. The precise mechanism for this is unknown. We hypothesized that this involves alteration in…

article 2011

Differential regulation of the neurotrophins, NGF and BDNF, and their receptors in the myometrium of women affected by adenomyosis

article 2011

Estrogen and progesterone receptor isoform distribution through the menstrual cycle in uteri with and without adenomyosis

Fertility and sterility ·doi:10.1016/j.fertnstert.2011.02.051

ObjectiveTo test the hypothesis that the expression of the different isoforms of the estrogen receptor alpha (ER-α) and beta (ER-β) and the progesterone receptor A (PR-A) and B (PR-B) would be differentially modulated in uteri with adenomyo…

article 2010

Enhanced invasion of stromal cells from adenomyosis in a three-dimensional coculture model is augmented by the presence of myocytes from affected uteri

Fertility and sterility ·doi:10.1016/j.fertnstert.2010.04.016

ObjectiveTo compare endometrial stromal cell invasion from women with and without adenomyosis and the effect of myometrial cells using a three-dimensional coculture.DesignCase-controlled blinded comparison.SettingUniversity department.Patie…

2009

Localisation and function of the endocannabinoid system in the human ovary.

PloS one ·doi:10.1371/journal.pone.0004579

BackgroundAlthough anandamide (AEA) had been measured in human follicular fluid and is suggested to play a role in ovarian follicle and oocyte maturity, its exact source and role in the human ovary remains unclear.Methods and findingsImmuno…

article 2006

Trimegestone differentially modulates the expression of matrix metalloproteinases in the endometrial stromal cell

·doi:10.1093/molehr/gal014

Matrix metalloproteinases (MMP) are considered to be of critical importance in the initiation of menstruation where MMP protein levels are reciprocally modulated by the actions of the gonadal steroid hormones, estradiol (E(2)) and progester…