Walton C

No ORCID on file · 1 paper in corpus

2016

Differential cathepsin responses to inhibitor-induced feedback: E-64 and cystatin C elevate active cathepsin S and suppress active cathepsin L in breast cancer cells.

The international journal of biochemistry & cell biology ·doi:10.1016/j.biocel.2016.08.030

Cathepsins are powerful proteases, once referred to as the lysosomal cysteine proteases, that have been implicated in breast cancer invasion and metastasis, but pharmaceutical inhibitors have suffered failures in clinical trials due to adve…