Jeng KW

No ORCID on file · 1 paper in corpus

article 2013

ADAM-10 and -17 regulate endometriotic cell migration via concerted ligand and receptor shedding feedback on kinase signaling

Proceedings of the National Academy of Sciences of the United States of America ·doi:10.1073/pnas.1222387110

A Disintegrin and Metalloproteinases (ADAMs) are the principal enzymes for shedding receptor tyrosine kinase (RTK) ectodomains and ligands from the cell surface. Multiple layers of activity regulation, feedback, and catalytic promiscuity im…