Marc St. George

No ORCID on file · 1 paper in corpus · active 2016

Study types

  • article 1
article 2016
RESEARCH ARTICLE Designing and Testing of Novel Taxanes to Probe the Highly Complex Mechanisms by Which Taxanes Bind to Microtubules and Cause Cytotoxicity to Cancer Cells

Our previous work identified an intermediate binding site for taxanes in the microtubule nanopore. The goal of this study was to test derivatives of paclitaxel designed to bind to this intermediate site differentially depending on the isoty…