Brennah Murphy

No ORCID on file · 2 papers in corpus

lab-animal 2023

975 Activation of myeloid cells by β-glucan clears disseminating ovarian cancer cells from the peritoneal fluid through macrophage-mediated clotting and omentum neutrophil extracellular traps

·doi:10.1136/jitc-2023-sitc2023.0975

Background Ovarian cancer (OvCa) is the most lethal gynecological cancer and the fifth leading cause of cancer-related deaths in women. Despite an initial positive response to therapy, most patients relapse and present with chemotherapy res…

lab-animal 2023

Targeting the mevalonate pathway suppresses ARID1A-inactivated cancers by promoting pyroptosis

Cancer cell ·doi:10.1016/j.ccell.2023.03.002

ARID1A, encoding a subunit of the SWI/SNF complex, is mutated in ∼50% of clear cell ovarian carcinoma (OCCC) cases. Here we show that inhibition of the mevalonate pathway synergizes with immune checkpoint blockade (ICB) by driving inflammas…