Beom-Jin Lee

ORCID: 0000-0003-0922-3289 · 3 papers in corpus
2024
Nanonization and Deformable Behavior of Fattigated Peptide Drug in Mucoadhesive Buccal Films.
Pharmaceutics ·doi:10.3390/pharmaceutics16040468

This study was tasked with the design of mucoadhesive buccal films (MBFs) containing a peptide drug, leuprolide (LEU), or its diverse nanoparticles (NPs), for enhanced membrane permeability via self-assembled nanonization and deformable beh…

other 2022
Determination of Leuprolide-Fatty Acid Conjugate in Rat Plasma Using LC-MS/MS and Its Pharmacokinetics after Subcutaneous Administration in Rats
Molecules (Basel, Switzerland) ·doi:10.3390/molecules27248716

Leuprolide is a synthetic nonapeptide drug (pyroGlu-His-Trp-Ser-Tyr-d-Leu-Leu-Arg-Pro-NHEt) that acts as a gonadotropin-releasing hormone agonist. The continuous administration of therapeutic doses of leuprolide inhibits gonadotropin secret…

2022
Hydroxyl Group-Targeted Conjugate and Its Self-Assembled Nanoparticle of Peptide Drug: Effect of Degree of Saturation of Fatty Acids and Modification of Physicochemical Properties.
International journal of nanomedicine ·doi:10.2147/ijn.s356804

PurposeTo conjugate different degree of saturation of C18 fatty acids (stearic acid, oleic acid, and linoleic acid) with the hydroxyl groups of leuprolide acetate (LEU acetate) and to investigate the controlled release and enhanced permeabi…