Fang Chen

INTRODUCTION: Adenomyosis is an enigmatic disease with estrogen dependence, and the exact pathogenic mechanisms remain confusing. Limited evidence points out the presence of gut flora changes in adenomyosis. However, evidence on how adenomy…

This article reports the clinical diagnosis and treatment of a 42-year-old female patient with a giant cervical leiomyoma, a rare condition. A review of the literature over the past 30 years reveals only one reported case of a cervical inte…

Protein O-GlcNAcylation is a post-translational modification coupled to cellular metabolic plasticity. Aberrant O-GlcNAcylation has been observed in many cancers including endometrial cancer (EC), a common malignancy in women. However, clin…

PURPOSE: To determine the differences in 3D shape features between septate uterus (SU) and normal uterus and to train a network to automatically delineate uterine cavity on 3D magnetic resonance imaging (MRI). METHODS: A total of 43 patien…

Endometriosis (EMs) is a prevalent chronic gynecological condition that depends on estrogen, marked by the presence of active endometrial tissue (glands and stroma) outside the uterus. Although pathologically benign, it exhibits biological …

RESEARCH QUESTION: Does LncRNA BANCR promote the malignant transformation of endometriosis by activating the miR-612/CPNE3 pathway? DESIGN: The expression patterns of BANCR, miR-612 and CPNE3 in normal endometrium, eutopic endometrium from…

Currently, the precise and detailed anatomical data of the normal uterus, especially the myometrium thickness in various parts of the uterus, are lacking. This study aims to provide normal references for uterine size in healthy reproductive…

Distal vaginal atresia is a rare abnormality of female reproductive tract in which the vagina is closed or absent. The distal vagina may be replaced by fibrous tissue and the condition is often not diagnosed until a girl fails to begin havi…

PURPOSE: To evaluate the effect of elevated sperm DNA fragmentation index (DFI) on fresh and frozen embryo transfer cycles. METHODS: A retrospective study was performed with 549 fresh embryo transfer cycles and 1340 frozen embryo transfer …

Fatty acids play important roles in maintaining ovarian steroidogenesis and endometrial receptivity. Porcine primary ovarian granulosa cells (PGCs) and endometrial epithelial cells (PEECs) were treated with or without medium- and short-chai…

BACKGROUND: To examine differences in the maternal characteristics and pregnancy outcomes of Chinese women with various causes of infertility who underwent in vitro fertilization (IVF) with embryonic cryopreservation treatment. METHODS: Ca…

ABSTRACT Purpose To evaluate the diagnostic value of Genome Sequencing(GS)in children with epilepsy. Methods We performed GS on 320 Chinese children with epilepsy and interpreted Single Nucleotide Variants (SNVs) and Copy Number Variant (CN…

PURPOSE: To investigate the potential role of Bone morphogenetic protein 1 (BMP1) in endometriosis lesions. METHODS: Endometriosis model in mice was established. The expression of BMP1-3 expression in mice of endometriosis lesions was eval…

PURPOSE: Intrauterine adhesion (IUA) is a fibrotic disease mainly caused by tissue injury, yet the mechanism is poorly understood. The aim of this study was to investigate the roles of TGF-β1/BMP7/Smad signaling coincident with epithelial-m…

BACKGROUND: To investigate the effect of applying doctor-nurse-patient integration management mode to patients with endometriosis (EMT). METHODS: A total of 160 patients with EMT from the Department of Neurology of The Fifth Affiliated Hos…

INTRODUCTION: A choristoma formed by heterotopic tissue rarely occurs in the throat, especially one accompanied with cleft palate in a new-born baby. PATIENT CONCERNS: An 18-month-old female patient was admitted to the hospital for apparen…

OBJECTIVE: To evaluate the effects of estradiol on endometrial regeneration and stromal fibrosis after endometrial curettage. STUDY DESIGN: This is an experimental, prospective study. Combining ovariectomized rabbits and different doses of…

BACKGROUND: Human follicular fluid (FF) is a unique biological fluid in which the oocyte develops in vivo, and presents an optimal source for non-invasive biochemical predictors. Oocyte quality directly influences the embryo development and…

BACKGROUND: Embryo selection has been based on developmental and morphological characteristics. However, the presence of an important intra-and inter-observer variability of standard scoring system (SSS) has been reported. A computer-assist…

Uteroplacental tissue plays a key role in substance exchanges between maternal and fetal circulation, and, therefore, in the growth and development of fetuses. In this study, proteomics and western blotting were applied to investigate the c…

OBJECTIVE: To investigate the effect and mechanism of the formation of intrauterine adhesion (IUA) at different dose of estrogen. METHODS: Thirty-three New Zealand female rabbits were randomly divided into low estrogen group, normal physio…