Kim H

The female reproductive system, including the endometrium, placenta, ovary, cervix, and fallopian tube, plays a critical role in conception, implantation, and fetal development. Recent advances in bioengineered models such as organoids, org…

Background/Objectives: The treatment options for endometriosis vary depending on individual needs and clinical circumstances. To preserve ovarian reserve, ethanol catheter-directed sclerotherapy may be considered as a treatment option. We c…

BACKGROUND: Leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5) is a well-established stem cell marker in multiple epithelial tissues. However, its spatial distribution and biological relevance in normal and pathological huma…

BACKGROUND: Endometrial cancer (ECa) is one of the most common gynecologic malignancies, with limited therapeutic responses in metastatic or recurrent cases. The bacterial microbiota has emerged as a key modulator of carcinogenesis and anti…

OBJECTIVE: To assess the associations of time to endometriosis diagnosis after presentation for pelvic pain between patients of different ages, races, ethnicities, and body mass index (BMI) ranges. METHODS: This retrospective study was con…

PURPOSE: To investigate whether the number of oocytes retrieved after controlled ovarian stimulation (COS) for fertility preservation (FP) can be predicted using serum anti-Müllerian hormone (AMH) levels in adolescent and young adult (AYA) …

Primary dysmenorrhea (PD) is characterized by excessive uterine contraction and ischemic vasoconstriction, primarily driven by elevated levels of prostaglandins (PGs; PGF2α) and inflammatory mediators. Nonsteroidal antiinflammatory drugs (N…

In mice, the uterus undergoes dynamic changes regulated by estrogen and progesterone during the estrous cycle. Proper regulation of these changes is critical for successful pregnancy. The Family with sequence similarity 3 (Fam3) gene family…

The association between uterine leiomyoma and migraine is unknown. This study aimed to explore the risk of uterine leiomyoma among women with migraine in reproductive age (i.e., 20-39 years). Using the Korean National Health Insurance Servi…

Background/Objectives: The prognosis of endometriosis-related ovarian clear cell carcinoma (OCCC) versus non-endometriosis-associated OCCC remains unclear. We examined the impact of endometriosis on OCCC diagnosis and progression and assess…

Background and Objectives: This systematic review and network meta-analysis evaluated the effects of postoperative opioid use on nausea and vomiting in women undergoing laparoscopic hysterectomy. Materials and Methods: A systematic search o…

IMPORTANCE: Embryo implantation is a hormone-regulated event requiring a receptive endometrium. In vitro models that simulate this process are essential for studying early embryonic development. Endometrial epithelial organoids (EEOs) provi…

Type 2 innate lymphoid cells (ILC2s) are an important source of innate cytokines that contribute to allergic inflammation. Recent studies have also suggested that ILC2s play a biological role in peripheral tissues such as lung, fat, intesti…

IMPORTANCE: The creation of robust maternal-embryonic interactions and implantation models is important for comprehending the early stages of embryonic development and reproductive disorders. Traditional two-dimensional (2D) cell culture sy…

OBJECTIVE: To describe the incidence of uterovaginal anomalies and histologic findings in transgender and nonbinary (TGNB) patients seeking hysterectomies. METHODS: All patients receiving gender-affirming hysterectomies between 2013 and 20…

Background and Objectives: Autonomic nervous system (ANS) disorders are responsible for primary dysmenorrhea and are closely linked to the spine. This study aims to evaluate the effects of sacroiliac joint manipulation on the ANS and lower …

The Gfo/Idh/MocA family enzyme DgpA was known to catalyze the regiospecific oxidation of puerarin to 3"-oxo-puerarin in the presence of 3-oxo-glucose. Here, we discovered that D3dgpA, dgpA cloned from the human gut bacterium Dorea sp. MRG-I…

PURPOSE: To determine whether patients with Marfan syndrome are at an increased risk for reproductive disorders. METHODS: This retrospective cohort study was conducted using the US collaborative network on the TriNetX research network of h…

PURPOSE: Multifetal gestation (MFG) is much more common in pregnancies that utilize assisted reproductive technologies (ART). We assessed how these rates have changed over the previous decade and the impact on live birth rates (LBR). METHO…

This study aimed to investigate the efficacy and safety of using optimized parameters obtained by computer simulation for ultrasound-guided high-intensity focused ultrasound (HIFU) treatment of uterine adenomyosis in comparison with convent…

The prevalence of genital human papillomavirus (HPV) in women with endometriosis has never been reported in a national representative survey. We aimed to investigate the association of endometriosis with the prevalence of HPV. We analyzed t…

Idiopathic pulmonary fibrosis (IPF) is a chronic, fatal, fibrotic, interstitial lung disease of unknown cause. Despite extensive studies, the underlying mechanisms of IPF development remain unknown. Here, we found that p300 was upregulated …

Liver fibrosis is caused by chronic liver damage and results in the aberrant accumulation of extracellular matrix during disease progression. Despite the identification of the HAT enzyme p300 as a major factor for liver fibrosis, the develo…