Ley TJ

ORCID: 0000-0002-9913-0520 · 1 paper in corpus

2021

Dnmt3a deficiency in the skin causes focal, canonical DNA hypomethylation and a cellular proliferation phenotype.

Proceedings of the National Academy of Sciences of the United States of America ·doi:10.1073/pnas.2022760118

DNA hypomethylation is a feature of epidermal cells from aged and sun-exposed skin, but the mechanisms responsible for this methylation loss are not known. Dnmt3a is the dominant de novo DNA methyltransferase in the skin; while epidermal Dn…