Koechling W

No ORCID on file · 1 paper in corpus

2010

Degarelix, a novel GnRH antagonist, causes minimal histamine release compared with cetrorelix, abarelix and ganirelix in an ex vivo model of human skin samples.

British journal of clinical pharmacology ·doi:10.1111/j.1365-2125.2010.03730.x

AimsEarly studies on gonadotrophin-releasing hormone (GnRH) antagonists pointed out histamine-mediated anaphylactic reactions as a potential adverse effect of these drug candidates. In this study we have compared the histamine-releasing pot…