Minhee Lee

No ORCID on file · 3 papers in corpus
rct 2020
First-in-Human, Double-Blind, Randomized Controlled Trial of an Oral Dose of GnRH Antagonist TU2670 in Healthy Women
The Journal of clinical endocrinology and metabolism ·doi:10.1210/clinem/dgaa939

OBJECTIVE: To evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of TU2670, a novel orally active, nonpeptide gonadotropin-releasing hormone (GnRH) antagonist administered to healthy female participants. METHODS: Thi…

case-report 2019
Posterior reversible encephalopathy syndrome in a woman who used gonadotropin-releasing hormone agonists: a case report
Obstetrics & Gynecology Science ·doi:10.5468/ogs.2019.62.1.69

Posterior reversible encephalopathy syndrome (PRES) is a newly described adverse effect possibly associated with gonadotropin-releasing hormone (GnRH) agonist therapy. We report a case of PRES after 2 doses of depot GnRH agonists in a 44-ye…

lab-animal 2009
Synthesis and biological evaluation of 3-(2-aminoethyl) uracil derivatives as gonadotropin-releasing hormone (GnRH) receptor antagonists
European Journal of Medicinal Chemistry ·doi:10.1016/j.ejmech.2017.12.095

We investigated a series of uracil analogues by introducing various substituents on the phenyl ring of the N-3 aminoethyl side chain and evaluated their antagonistic activity against human gonadotropin-releasing hormone (GnRH) receptors. An…