Shruthi Mahalingaiah

BACKGROUND: Personal care products (PCPs) may contain endocrine-disrupting chemicals (EDCs) that can impact menstrual health. Despite widespread usage, little is known about the associations of PCP usage, EDC avoidance, and menstrual cycle …

Although the menstrual cycle is a vital sign for women's health, research investigating menstrual cycle length (MCL) trajectories across reproductive life is scarce, often categorizing just two patterns: regular and irregular. We used laten…

Objective: To study the prevalence of co-occurring endometriosis and polyendocrine metabolic ovarian syndrome (PMOS), estimate infertility odds, and characterize menstrual symptom profiles associated with this combined phenotype in a popula…

BACKGROUND: Polycystic ovary syndrome is a common endocrine disorder, characterized by oligomenorrhea and androgen excess. Only a few studies have addressed the natural history of menstrual cycles among women with polycystic ovary syndrome …

BACKGROUND: Using menstrual products is a part of managing menstrual bleeding. Product use may represent individual, social, and economic influences. A few studies on menstrual product use from specific regions in the United States reported…

STUDY QUESTION: Can algorithms using wrist temperature, available on compatible models of iPhone and Apple Watch, retrospectively estimate the day of ovulation and predict the next menses start day? SUMMARY ANSWER: Algorithms using wrist t…

Some medical professional organizations have advocated for including the menstrual cycle as a vital sign in adolescence, but not in adulthood. However, documenting menstrual cycle patterns is not routine clinical or research practice. Vital…

The menstrual cycle is an underutilized but powerful tool for understanding gynecological and general health across the lifespan. However, menstrual-related concerns are often underdiagnosed or ignored. Reasons for the underdiagnosis and ne…

BACKGROUND: Use of menstrual tracking data to understand abnormal bleeding patterns has been limited because of lack of incorporation of key demographic and health characteristics and confirmation of menstrual tracking accuracy. OBJECTIVE:…

BACKGROUND: Menstrual cycle tracking apps (MCTAs) have potential in epidemiological studies of women's health, facilitating real-time tracking of bleeding days and menstrual-associated signs and symptoms. However, information regarding the …

BACKGROUND: Prospective longitudinal cohorts assessing women's health and gynecologic conditions have historically been limited. OBJECTIVE: The Apple Women's Health Study was designed to gain a deeper understanding of the relationship amon…

The aim of this study is to determine the most informative pre- and in-cycle variables for predicting success for a first autologous oocyte in-vitro fertilization (IVF) cycle. This is a retrospective study using 22,413 first autologous oocy…

BACKGROUND: Solar ultraviolet radiation (UV) is a critical environmental factor for dermal conversion of vitamin D, which is suggested to support reproductive health. However, current epidemiological studies have reported conflicting result…

BACKGROUND: Recent epidemiologic research shows many environmental chemicals exhibit endocrine disrupting effects on the female reproductive system. Few studies have examined exposure at reproductive organs. Our aim was to perform a prelimi…

UNLABELLED: Previous studies have suggested noise, especially at night time, and light at night (LAN) could cause neuroendocrine disturbance and circadian disruption, which may lead to ovarian follicle atresia and earlier onset of menopause…

Evidence has shown associations between air pollution and traffic-related exposure with accelerated aging, but no study to date has linked the exposure with age at natural menopause, an important indicator of reproductive aging. In this stu…

PURPOSE OF REVIEW: The aim of this review is to evaluate biological, life history, environmental, and lifestyle factors and exposures that cause variability in menstrual cycle length (MCL). RECENT FINDINGS: Recent literature has detailed a…

BACKGROUND: Multimodal recruitment strategies are a novel way to increase diversity in research populations. However, these methods have not been previously applied to understanding the prevalence of menstrual disorders such as polycystic o…

ObjectiveTo determine the dose-dependent effect of contemporary marijuana exposure on female menstrual cyclicity and reproductive endocrine physiology in a nonhuman primate model.DesignResearch animal study.SettingResearch institute environ…

PURPOSE OF REVIEW: The goal of this review was to evaluate whether the fields available in iOS mobile phone apps for recording menstrual cycle symptoms are able to be harmonized across platforms for potential use in research, such as aggreg…

Exposure to phthalates, endocrine-disrupting chemicals commonly used as plasticizers and in consumer products, has been associated with infertility and premature ovarian failure. Our objective was to investigate whether urinary phthalate me…

While issues of environmental justice have highlighted populations at high risk of adverse health outcomes due to air pollution, chemical exposures, and land use, how these disparate exposures might uniquely impact women’s health is a…

BACKGROUND: Amongst women with certain types of ovulatory disorder infertility, the studies are conflicting whether there is an increased risk of long-term cardiovascular disease risk. This paper evaluates the associations of several CVD ri…

STUDY QUESTION: Is there an association between air pollution exposures and incident infertility? SUMMARY ANSWER: Increased exposure to air pollution is associated with an increased incidence of infertility. WHAT IS KNOWN ALREADY: Exposur…