Carmen Cardá

Pain, the most common symptom in endometriosis, has been reported in up to 50% of patients. Human peritoneal endometriotic lesions are innervated by nerve fibers that appear to be responsible for much of the pain and local tenderness. A num…

ObjectiveTo investigate the effect of antiangiogenic treatment on experimental endometriotic lesion nerve fibers.DesignHeterologous mouse model of endometriosis.SettingUniversity Institute IVI, University Hospital La Fe.Animal(s)Ovariectomi…

Previous studies in an experimental mouse model of endometriosis have shown that the dopamine agonist (DA) cabergoline (Cb2) reduces angiogenesis and endometriotic lesions, hypothetically binding to the dopamine receptor type-2 (DRD2). To d…

BACKGROUND: Implantation of a retrogradely-shed endometrium during menstruation requires an adequate blood supply. The endometrium has angiogenic potential, and endometriotic lesions grow in areas with a rich vascularization, suggesting tha…

Survival of newly implanted retrograde–shed endometrial tissue during menstruation in an ectopic location requires an adequate blood supply. This suggests that angiogenesis is a prerequisite for the development of endometriosis and that its…

also sensitized ESC to Fas-mediated apoptosis, but this effect seems not to be mediated by the downregulation of FLIP, an inhibitor of caspase-8 activation. Conclusion: In summary, we demonstrate that human ESC are primarily resistant to ap…