Saunders J

No ORCID on file · 2 papers in corpus

2025

Atrial Mass in Pregnancy: A Rare Case of Intracardiac Ectopic Liver.

Annals of thoracic surgery short reports ·doi:10.1016/j.atssr.2025.02.006

We report a case of a 41-year-old female who was found to have a 2.7-cm right atrial mass during the third trimester of her pregnancy. She underwent successful surgical resection 4 months after an uneventful delivery. Pathologic examination…

other 2008

Discovery of sodium R-(+)-4-{2-[5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyrate (elagolix), a potent and orally available nonpeptide antagonist of the human gonadotropin-releasing hormone receptor

Journal of medicinal chemistry ·doi:10.1021/jm8006454

The discovery of novel uracil phenylethylamines bearing a butyric acid as potent human gonadotropin-releasing hormone receptor (hGnRH-R) antagonists is described. A major focus of this optimization was to improve the CYP3A4 inhibition liabi…