Stucki M

No ORCID on file · 2 papers in corpus

article 2019

Doxycycline reduces MMP-2 activity and inhibits invasion of 12Z epithelial endometriotic cells as well as MMP-2 and -9 activity in primary endometriotic stromal cells in vitro

Reproductive biology and endocrinology : RB&E ·doi:10.1186/s12958-019-0481-z

BACKGROUND: Matrix metalloproteinases (MMPs), especially the gelatinases MMP-2 and MMP-9, play a crucial role in the pathogenesis of endometriosis by enabling invasion. Doxycycline is a well-tolerated antibiotic and a potent MMP-inhibitor i…

2014

Loss of ARID1A expression sensitizes cancer cells to PI3K- and AKT-inhibition.

Oncotarget ·doi:10.18632/oncotarget.2092

ARID1A mutations are observed in various tumors, including ovarian clear cell (OCCC) and endometrioid carcinomas, endometrial, and breast carcinomas. They commonly result in loss of ARID1A-protein expression and frequently co-occur with PI3…