André G Uitterlinden

other 2023

Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus

Nature human behaviour ·doi:10.1038/s41562-023-01528-6

Identifying genetic determinants of reproductive success may highlight mechanisms underlying fertility and identify alleles under present-day selection. Using data in 785,604 individuals of European ancestry, we identified 43 genomic loci a…

2018

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

Nature genetics ·doi:10.1038/s41588-017-0011-x

Genome-wide association studies (GWAS) have identified >250 loci for body mass index (BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters of common, noncoding variants from which pinpointing causal gene…

2016

Genome-wide analysis identifies 12 loci influencing human reproductive behavior.

Nature genetics ·doi:10.1038/ng.3698

The genetic architecture of human reproductive behavior-age at first birth (AFB) and number of children ever born (NEB)-has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. However, …

2016

Genome-wide associations for birth weight and correlations with adult disease.

Nature ·doi:10.1038/nature19806

Birth weight (BW) has been shown to be influenced by both fetal and maternal factors and in observational studies is reproducibly associated with future risk of adult metabolic diseases including type 2 diabetes (T2D) and cardiovascular dis…