Serum butyrylcholinesterase (BCHE) activity is associated with obesity, blood pressure and biomarkers of cardiovascular and diabetes risk. We have conducted a genome-wide association scan to discover genetic variants affecting BCHE activity…
The progesterone receptor (PR) is a candidate gene for the development of endometriosis, a complex disease with strong hormonal features, common in women of reproductive age. We typed the 306 base pair Alu insertion (AluIns) polymorphism in…
Endometriosis is a common gynecological disease that affects up to 10% of women in their reproductive years. It causes pelvic pain, severe dysmenorrhea, and subfertility. The disease is defined as the presence of tissue resembling endometri…
OBJECTIVE: The aim of the International Endogene Study is to discover genes that influence susceptibility to endometriosis. DESIGN: The study brings together two research groups based in Australia and the United Kingdom that independently …
ObjectiveTo investigate the prevalence of and twin pair concordance for endometriosis.DesignA questionnaire survey incorporating validation.SettingAn Australia-wide volunteer sample of female monozygotic (MZ) and dizygotic (DZ) twin pairs f…
ObjectiveWe evaluated the relative importance of predictors of hysterectomy.Study designA questionnaire survey of an Australia-wide sample of adult female twins was conducted; self-report data were validated against reports from treating ph…