Beck KR

ORCID: 0000-0001-9818-1265 · 2 papers in corpus · active 2015-2017
2017
Virtual screening applications in short-chain dehydrogenase/reductase research.
The Journal of steroid biochemistry and molecular biology ·doi:10.1016/j.jsbmb.2017.03.008

Several members of the short-chain dehydrogenase/reductase (SDR) enzyme family play fundamental roles in adrenal and gonadal steroidogenesis as well as in the metabolism of steroids, oxysterols, bile acids, and retinoids in peripheral tissu…

2015
Pharmacophore Models and Pharmacophore-Based Virtual Screening: Concepts and Applications Exemplified on Hydroxysteroid Dehydrogenases.
Molecules (Basel, Switzerland) ·doi:10.3390/molecules201219880

Computational methods are well-established tools in the drug discovery process and can be employed for a variety of tasks. Common applications include lead identification and scaffold hopping, as well as lead optimization by structure-activ…