Pietzner M

ORCID: 0000-0003-3437-9963 · 2 papers in corpus

2025

A computational framework for defining and validating reproducible phenotyping algorithms of 313 diseases in the UK Biobank.

Scientific reports ·doi:10.1038/s41598-025-05838-9

Accurate and reproducible phenotyping is essential for large-scale biomedical research. However, developing robust phenotype definitions in biobanks is challenging due to diverse data sources and varying medical ontologies. As a result, the…

2023

Lowering of Circulating Sclerostin May Increase Risk of Atherosclerosis and Its Risk Factors: Evidence From a Genome-Wide Association Meta-Analysis Followed by Mendelian Randomization.

Arthritis & rheumatology (Hoboken, N.J.) ·doi:10.1002/art.42538

ObjectiveIn this study, we aimed to establish the causal effects of lowering sclerostin, target of the antiosteoporosis drug romosozumab, on atherosclerosis and its risk factors.MethodsA genome-wide association study meta-analysis was perfo…