Morales Granda NC

No ORCID on file · 1 paper in corpus

lab-animal 2023

Mouse model of PRSS1 p.R122H-related hereditary pancreatitis highlights context-dependent effect of autolysis-site mutation.

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] ·doi:10.1016/j.pan.2023.02.003

Mutation p.R122H in human cationic trypsinogen (PRSS1) is the most frequently identified cause of hereditary pancreatitis. The mutation blocks protective degradation of trypsinogen by chymotrypsin C (CTRC), which involves an obligatory tryp…