Abstract Elagolix sodium is a novel, orally active non-peptide GnRH receptor antagonist used to treat endometriosis and uterine fibroids, as a BCS class III drug, it exhibits high solubility but low permeability, leading to poor and vari…
Objective: To validate a scoring system aims to triage women with heavy menstrual bleeding (HMB) into hysterectomy or uterine sparing options and inform the development of a prospective clinical trial. Design: Retrospective study. Setting:…
Ferroptosis, a form of regulated cell death, has emerged as a crucial process in diverse pathophysiological states, encompassing cancer, neurodegenerative ailments, and ischemia-reperfusion injury. The glutathione (GSH)-dependent lipid pero…
Estradiol-BODIPY linked via an 8-carbon spacer chain and 19-nortestosterone- and testosterone-BODIPY linked via an ethynyl spacer group were evaluated for cell uptake in the breast cancer cell lines MCF-7 and MDA-MB-231 and prostate cancer …
Spinal epidural lipomatosis (SEL) is a rare condition in which fat accumulates in the epidural space. Patients may be asymptomatic or present with neurologic symptoms if the spinal cord is compressed. Based on the pathophysiology of this co…