Sousa D

ORCID: 0009-0007-8170-9941 · 3 papers in corpus
lab-animal 2026
Follicular fluid from women with polycystic ovary syndrome induces granulosa cells metabolic dysfunction that is exacerbated by obesity
Frontiers in endocrinology ·doi:10.3389/fendo.2026.1783780

BACKGROUND: Polycystic ovary syndrome (PCOS) is characterized by altered follicular development and metabolic dysfunction, frequently exacerbated by obesity. The follicular fluid (FF) microenvironment plays a critical role in supporting ooc…

observational 2025
Polycystic ovary syndrome and excessive body weight impact independently and synergically on fertility treatment outcomes
Reproductive biology and endocrinology : RB&E ·doi:10.1186/s12958-025-01434-8

BACKGROUND: Polycystic ovary syndrome (PCOS) and obesity can both disrupt reproductive function. However, the extent to which obesity contributes to PCOS manifestations is not very clear. This study aimed to disentangle the relative contrib…

observational 2024
Cumulus cell DNA damage linked to fertilization success in females with an ovulatory dysfunction phenotype
Frontiers in cell and developmental biology ·doi:10.3389/fcell.2024.1448733

Intracytoplasmic sperm injection (ICSI) is a widely used technique in fertility centers. ICSI success depends on both nuclear and cytoplasmic oocyte maturation. Cumulus cells, which surround the oocytes, play a pivotal role in oocyte compet…