Zhenzhen Chen

ORCID: 0000-0001-9919-3997 · 3 papers in corpus
lab-animal 2026
Mechanisms of IL-17A Neutralisation in Alleviating Renal Fibrosis and Inflammation in Spontaneously Hypertensive Rats
Clinical and experimental pharmacology & physiology ·doi:10.1111/1440-1681.70116

OBJECTIVE: This study investigated the therapeutic effects and mechanisms of IL-17A neutralisation on renal interstitial fibrosis and inflammation in spontaneously hypertensive rats (SHRs). METHODS: SHRs were treated with an IL-17A-neutral…

lab-animal 2023
Tanshinone ⅡA participates in the treatment of endometriosis by regulating adhesion, invasion, angiogenesis and inhibition of PI3K/Akt/mTOR signaling pathway
Molecular medicine reports ·doi:10.3892/mmr.2023.13108

Endometriosis (EMs) is a common gynecological disorder characterized by abnormal growth of the endometrial stroma and glands outside the uterus. Tanshinone IIA, the active component of Chinese medicine Danshen (Salvia miltiorrhiza Bge.), ha…

lab-animal 2019
Tanshinone IIA contributes to the pathogenesis of endometriosis via renin angiotensin system by regulating the dorsal root ganglion axon sprouting
Life sciences ·doi:10.1016/j.lfs.2019.117085

AIMS: Our study was designed to explore the function and mechanism of Tanshinone IIA in alleviating pain syndrome caused by endometriosis (EMs). MAIN METHODS: Female Sprague-Dawley rats went through autotransplantation operation to establi…