William F. Crowley

No ORCID on file · 4 papers in corpus
review 2011
The role of the prokineticin 2 pathway in human reproduction: evidence from the study of human and murine gene mutations
Endocrine Reviews ·doi:10.1210/er.2010-0007

A widely dispersed network of hypothalamic GnRH neurons controls the reproductive axis in mammals. Genetic investigation of the human disease model of isolated GnRH deficiency has revealed several key genes crucial for GnRH neuronal ontogen…

lab-animal 2010
A high-throughput small-molecule ligand screen targeted to agonists and antagonists of the G-protein-coupled receptor GPR54
Journal of biomolecular screening ·doi:10.1177/1087057110369701

Recent data have shown that the G-protein-coupled receptor GPR54 (also known as KiSS-1 receptor) regulates GnRH release from the hypothalamus. This essential role of GPR54 in controlling the hypothalamic-pituitary-gonadal axis makes it an a…

other 2006
Continuous human metastin 45-54 infusion desensitizes G protein-coupled receptor 54-induced gonadotropin-releasing hormone release monitored indirectly in the juvenile male Rhesus monkey (Macaca mulatta): a finding with therapeutic implications
Endocrinology ·doi:10.1210/en.2005-1550

The effect of continuous administration of the C-terminal fragment of metastin, the ligand for the G protein-coupled receptor, GPR54, on GnRH-induced LH secretion was examined in three agonadal, juvenile male monkeys whose responsiveness to…

review 1991
Gonadotropin-releasing hormone and its analogues
New England Journal of Medicine ·doi:10.1056/nejm199101103240205

RESEARCH into the neuroendocrine control of reproduction by gonadotropin-releasing hormone (GnRH) has witnessed a remarkable two decades. From the isolation and chemical characterization of GnRH in 1971 through the awarding of the Nobel Pri…