Kazemier B

No ORCID on file · 1 paper in corpus · active 2012
2012
X-ray structures of progesterone receptor ligand binding domain in its agonist state reveal differing mechanisms for mixed profiles of 11β-substituted steroids.
The Journal of biological chemistry ·doi:10.1074/jbc.m111.308403

We present here the x-ray structures of the progesterone receptor (PR) in complex with two mixed profile PR modulators whose functional activity results from two differing molecular mechanisms. The structure of Asoprisnil bound to the agoni…