Melanie Davies

The average age of childbirth in the UK in 2022 was 30.9 years, having increased by over 3 years in the past 2 decades, and 4 years since 1980. Although a woman's fertility declines markedly in her late-30s and early-40s, more women are now…

AbstractMenopause following cancer treatment is an increasingly recognised component of survivorship yet remains under-addressed in clinical care. The aim of this review was to synthesise current evidence on menopause induced by cancer trea…

STUDY QUESTION: How should premature/primary ovarian insufficiency (POI) be diagnosed and managed based on the best available evidence from published literature? SUMMARY ANSWER: The current guideline provides 145 recommendations on symptom…

Fertility preservation (FP) is an established and recognised intervention for those undergoing gonadotoxic treatments, principally for malignancy. The surgical treatment of endometrioma and the disease itself reduce ovarian reserve and has …

This paper deals with the use of hormone replacement therapy (HRT) after the removal of fallopian tubes and ovaries to prevent ovarian cancer in premenopausal high risk women. Some women have an alteration in their genetic code, which makes…

OBJECTIVE: To investigate the risks of ovarian, breast, and corpus uteri cancer in women who have had assisted reproduction. DESIGN: Large, population based, data linkage cohort study. SETTING AND PARTICIPANTS: All women who had assisted …

#### What you need to know Endometriosis is one of the most common gynaecological disorders, affecting an estimated 10% of women in the reproductive age group (usually 15-49 years old), and in the UK it is the second most common gynaecolog…

BACKGROUND: Premature ovarian insufficiency (POI), often and misleadingly referred to as 'premature menopause', is defined as a loss of ovarian activity before the age of 40 years and is characterized by irregular or absent periods and redu…

STUDY QUESTION: What is the optimal management of women with premature ovarian insufficiency (POI) based on the best available evidence in the literature? SUMMARY ANSWER: The guideline development group (GDG) formulated 99 recommendations …

To assess long-term health effects of ovarian-stimulation drugs we followed-up for over 20 years a British cohort of 7355 women with ovulatory disorders, 43% of whom were prescribed ovarian-stimulation drugs, and identified a total of 274 d…

Abstract Endometriosis is commonly found at laparoscopy in women who have had children as well as in women who are infertile. It is not a cancer and rarely changes into a cancer. It can cause pain: painful periods, pain for several days bef…

Pregnancies in women older than 35 are increasing markedly in Western countries.1 Some commentators believe that this demographic shift poses a small or manageable problem as there are compensatory successful fertility treatments. However, …

The treatment options that face a couple prior to in vitro fertilisation (IVF) depend upon the cause of their infertility. To clarify the definition of male factor subfertility to produce a pragmatic approach to treatment, Van Voorhis publi…