Martin Hirst

ORCID: 0000-0001-9136-9054 · 3 papers in corpus · active 2010-2015

Study types

  • article 3

Condition tags

  • endometriosis 3
  • mesh:D004715 2
article 2015
Multifocal endometriotic lesions associated with cancer are clonal and carry a high mutation burden
The Journal of Pathology ·doi:10.1002/path.4516

Endometriosis is a significant risk factor for clear cell and endometrioid ovarian cancers and is often found contiguous with these cancers. Using whole-genome shotgun sequencing of seven clear cell ovarian carcinomas (CCC) and targeted seq…

article 2014
Abstract LB-312: The somatic mutational landscape of ovarian clear cell carcinoma and its precursor lesions
·doi:10.1158/1538-7445.am2014-lb-312

Abstract Clear Cell ovarian carcinomas (CCC) represent ∼10% of ovarian carcinomas, with outcomes for high-stage cases significantly worse than the more common high-grade serous form. Response to standard chemotherapies are poor and efforts …

article 2010
ARID1A Mutations in Endometriosis-Associated Ovarian Carcinomas
The New England journal of medicine ·doi:10.1056/nejmoa1008433

BACKGROUND: Ovarian clear-cell and endometrioid carcinomas may arise from endometriosis, but the molecular events involved in this transformation have not been described. METHODS: We sequenced the whole transcriptomes of 18 ovarian clear-ce…