Jonathan Tyrer

No ORCID on file · 3 papers in corpus
other 2015
Cell-type-specific enrichment of risk-associated regulatory elements at ovarian cancer susceptibility loci
Human molecular genetics ·doi:10.1093/hmg/ddv101

Understanding the regulatory landscape of the human genome is a central question in complex trait genetics. Most single-nucleotide polymorphisms (SNPs) associated with cancer risk lie in non-protein-coding regions, implicating regulatory DN…

article 2015
Evidence of a genetic link between endometriosis and ovarian cancer
Fertility and sterility ·doi:10.1016/j.fertnstert.2015.09.023

ObjectiveTo evaluate whether endometriosis-associated genetic variation affects risk of ovarian cancer.DesignPooled genetic analysis.SettingUniversity hospital.Patient(s)Genetic data from 46,176 participants (15,361 ovarian cancer cases and…

other 2014
Risk of ovarian cancer and the NF-κB pathway: genetic association with IL1A and TNFSF10
Cancer research ·doi:10.1158/0008-5472.CAN-13-1051

A missense single-nucleotide polymorphism (SNP) in the immune modulatory gene IL1A has been associated with ovarian cancer risk (rs17561). Although the exact mechanism through which this SNP alters risk of ovarian cancer is not clearly unde…