Freedman ML
No ORCID on file
· 6 papers in corpus
· active 2020-2024
Study types
- meta-analysis 1
- preprint 1
Condition tags
- endometriosis 2
Top journals
Frequent coauthors
- Karlan BY 5
- Gayther SA 5
- Kate Lawrenson 5
- Siddhartha P Kar 4
- Campbell I 3
- Plummer JT 3
- Pharoah P 3
- Jones MR 3
- Huntsman DG 3
- Hazelett DJ 3
2024
To identify credible causal risk variants (CCVs) associated with different histotypes of epithelial ovarian cancer (EOC), we performed genome-wide association analysis for 470,825 genotyped and 10,163,797 imputed SNPs in 25,981 EOC cases an…
meta-analysis
2022
Endometriosis is associated with increased risk of epithelial ovarian cancers (EOCs). Using data from large endometriosis and EOC genome-wide association meta-analyses, we estimate the genetic correlation and evaluate the causal relationshi…
2022
BackgroundKnown risk alleles for epithelial ovarian cancer (EOC) account for approximately 40% of the heritability for EOC. Copy number variants (CNVs) have not been investigated as EOC risk alleles in a large population cohort.MethodsSingl…
preprint
2021
Abstract Endometriosis is associated with increased risk of epithelial ovarian cancers (EOCs). Data from large endometriosis and EOC genome-wide association meta-analyses were used to estimate the genetic correlation and evaluate the causal…
2020
The functional consequences of somatic non-coding mutations in ovarian cancer (OC) are unknown. To identify regulatory elements (RE) and genes perturbed by acquired non-coding variants, here we establish epigenomic and transcriptomic landsc…
2020
Quantifying the functional effects of complex disease risk variants can provide insights into mechanisms underlying disease biology. Genome-wide association studies have identified 39 regions associated with risk of epithelial ovarian cance…