Agnew DW

Animal models of human disease have been used for a long time, and frequently, diseases in these models are induced, rather than spontaneous. The present review outlines several examples of naturally occurring reproductive diseases in non-d…

Loss of heterozygosity and promoter hypermethylation of APC is frequently observed in human endometrial cancer, which is the most common gynecological cancer in the USA, but its carcinogenic driver status in the endometrial epithelium has n…