Jay E Wrobel

No ORCID on file · 3 papers in corpus · active 2005-2010

Study types

  • other 2
  • review 1

Condition tags

  • endometriosis 3
other 2010
Synthesis and biological evaluation of piperazinyl heterocyclic antagonists of the gonadotropin releasing hormone (GnRH) receptor
Bioorganic & medicinal chemistry letters ·doi:10.1016/j.bmcl.2010.02.099

Antagonism of the gonadotropin releasing hormone (GnRH) receptor has resulted in positive clinical results in reproductive tissue disorders such as endometriosis and prostate cancer. Following the recent discovery of orally active GnRH anta…

other 2008
Design, synthesis, and SAR of new pyrrole-oxindole progesterone receptor modulators leading to 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile (WAY-255348)
Journal of medicinal chemistry ·doi:10.1021/jm701080t

We have continued to explore the 3,3-dialkyl-5-aryloxindole series of progesterone receptor (PR) modulators looking for new agents to be used in female healthcare: contraception, fibroids, endometriosis, and certain breast cancers. Previous…

review 2005
Nonsteroidal progesterone receptor modulators: structure activity relationships
Seminars in reproductive medicine ·doi:10.1055/s-2005-864033

Progesterone, acting primarily via the progesterone receptor (PR), plays an essential role in the regulation of female reproduction. Steroidal progestins (i.e., PR agonists) are commonly used in women's health, such as in contraception and …