Zhang X

ETHNOPHARMACOLOGICAL RELEVANCE: Gonadotropin-releasing hormone agonists (GnRH-a) often induce menopausal symptoms, negatively affecting women's psychological, emotional, and physical health. Kuntai capsule is widely used in clinical practic…

Endometriosis, a prevalent gynecological disease affecting women's health, involves altered immune function. This study investigates the immune checkpoint protein, V-domain immunoglobulin suppressor of T cell activation (VISTA) as a therape…

IntroductionAcute pancreatitis (AP) is an inflammatory pancreatic disorder with potentially severe systemic consequences. While its immediate clinical impact is well established, the long-term multisystem comorbidities of AP remain underexp…

The present study investigated the role of melatonin (MT) in regulating mitochondrial function via sirtuin 3 (SIRT3) in granulosa cells (GCs) from patients with polycystic ovary syndrome (PCOS), with a focus on mitochondrial protection. Not…

OBJECTIVE: To describe a mesentery-preserving, nerve-sparing laparoscopic technique for rectal endometriosis. DESIGN: Retrospective cohort study. SETTING: Single centre. POPULATION OR SAMPLE: Women requiring bowel resection for rectal en…

Metabolism-regulating microspheres have evolved from conventional drug carriers into active platforms capable of spatiotemporally reprogramming pathological metabolic networks. Chronic diseases are increasingly understood to be driven by me…

Metabolic determinants of oocyte quality and embryonic development remain incompletely understood. Here, we profiled metabolites in human cumulus cells (CCs) and follicular fluid (FF), validated in two mouse models, and integrated transcrip…

BACKGROUND: Nerve growth factor (NGF), which acts on receptors tropomyosin receptor kinase A and p75 neurotrophic receptor, is a member of neurotrophin family and a kind of secretory polypeptides. METHODS: A comprehensive literature search…

Gastric metastasis from breast cancer (GMBC) is a rare but diagnostically challenging condition, whose clinical and imaging features often mimic primary gastric cancer or treatment-related adverse effects. This study integrates a detailed c…

Gynecologic disorders, including infections, sterile inflammatory diseases, endocrine abnormalities, and malignancies, share a common signature of dysregulated immunity within a uniquely hormone-responsive reproductive tract. Neutrophil ext…

Obesity triggers ovarian dysfunction and female infertility accompanied by granulosa cell damage. Ferroptosis, iron-dependent lipid peroxidation-mediated cell death, participates in multiple reproductive diseases, yet the molecular cascade …

OBJECTIVE: To investigate oncological and reproductive outcomes in patients with mismatch repair-deficient (MMRd) endometrial endometrioid carcinoma (EEC) or atypical endometrial hyperplasia (AEH) undergoing fertility-preserving treatment t…

OBJECTIVE: To systematically evaluate the associations between paternal factors (age, semen parameters, body mass index, sperm DNA fragmentation index (DFI), and leukocyte count), embryonic ploidy, and the clinical implantation potential of…

This narrative review first summarizes current treatment strategies and postoperative prevention measures for intrauterine adhesions (IUAs), then discusses prognostic factors associated with pregnancy outcomes and recent advances in predict…

Exosomes, as key mediators of intercellular communication, play a central regulatory role in cellular physiological and pathological processes through their dynamic interaction with the cytoskeleton. The cytoskeleton is a dynamic network co…

Varicocele-induced decline in sperm quality is a common cause of male infertility. While varicocelectomy improves semen parameters, the mechanisms remain unclear. Recent studies suggested that small noncoding RNAs (sncRNAs) in sperm play a …

BACKGROUND/AIMS: Age-related macular degeneration (AMD) is a progressive degenerative disease of the retinal macula associated with aging, which is one of the main causes of vision loss in the elderly. This research aims to investigate the …

BACKGROUND: Adenomyosis occurs when tissue from the inner lining of the endometrium grows into the muscle wall of the myometrium. Previous studies have suggested that High-Intensity Focused Ultrasound (HIFU) combined with medications may im…

Acute pancreatitis is a complex inflammatory disease with high morbidity and mortality, closely associated with intestinal barrier dysfunction, gut microbiota dysbiosis and abnormal lipid metabolism. Akkermansia muciniphila has been shown t…

BackgroundUreteral reimplantation (UR) is the standard treatment for distal ureteral stricture, yet postoperative anastomotic restenosis impairs outcomes, with conventional imaging unable to quantify urinary tract obstruction and dysfunctio…

This study investigates the molecular mechanism by which USP25 contributes to pancreatic microcirculatory disturbance in severe acute pancreatitis (SAP). SAP was induced by retrograde injection of 4% sodium taurocholate into the pancreatic …

ObjectiveThis study aimed to elucidate the functional role and regulating mechanism of Total Glucosides of Paeony (TGP) in chronic endometritis (CE).MethodsTo assess the impact of TGP on CE, a CE rat model was established via infusion with …

Abstract Ferroptosis is linked to various diseases, but the role of transferrin (TF) in endometriosis (EM) remains unclear. Expression levels of ferroptosis-related proteins, including transferrin (TF), transferrin receptor (TFRC), and glut…

BackgroundThe Ovarian-Adnexal Reporting and Data System (O-RADS) ultrasound (US) is a standardized tool for assessing adult adnexal lesions, but its performance in the pediatric population has not been fully validated. This study aimed to v…

"Wen Tong Plaster" is renowned for its therapeutic effects of warming meridians, dispelling cold, and promoting blood circulation. However, its chemical composition and active pharmacological substances have yet to be fully elucidated. In t…