Davis JW

No ORCID on file · 4 papers in corpus
2022
The landscape of GWAS validation; systematic review identifying 309 validated non-coding variants across 130 human diseases.
BMC medical genomics ·doi:10.1186/s12920-022-01216-w

BackgroundThe remarkable growth of genome-wide association studies (GWAS) has created a critical need to experimentally validate the disease-associated variants, 90% of which involve non-coding variants.MethodsTo determine how the field is …

article 2013
Developmental exposure of fetal ovaries and fetal germ cells to endometriosis in an endometriosis model causes differential gene expression in the preimplantation embryos of the first-generation and second-generation embryos
Fertility and sterility ·doi:10.1016/j.fertnstert.2013.07.007

ObjectiveTo characterize multigenerational gene expression anomalies in eight-cell stage embryos associated with developmental exposure to endometriosis.DesignUsing an endometriosis model in rats (F0 founder generation) to evaluate gene exp…

other 2010
Inflammatory cytokines differentially up-regulate human endometrial haptoglobin production in women with endometriosis
Human Reproduction ·doi:10.1093/humrep/deq032

BACKGROUND: Evidence suggests that eutopic endometrium from women with endometriosis (US-E) has intrinsic functional anomalies compared with women without endometriosis (US-C). We hypothesized that differences in endometrial haptoglobin (eH…

article 2009
Aberrant gene expression profile in a mouse model of endometriosis mirrors that observed in women
Fertility and sterility ·doi:10.1016/j.fertnstert.2009.03.086

ObjectiveTo define the altered gene expression profile of endometriotic lesions in a mouse model of surgically induced endometriosis.DesignAutologous experimental mouse model.SettingMedical school department.Animal(s)Adult C57Bl6 mice.Inter…