He‐Feng Huang

ORCID: 0000-0002-0195-985X · 11 papers in corpus
2025
Preimplantation genetic testing for aneuploidy versus no genetic testing in couples undergoing intracytoplasmic sperm injection for severe male infertility: multicentre, open label, randomised controlled trial.
BMJ (Clinical research ed.) ·doi:10.1136/bmj-2025-084050

ObjectiveTo assess the efficacy of preimplantation genetic testing for aneuploidies (PGT-A) compared to intracytoplasmic sperm injection (ICSI) alone in couples undergoing ICSI treatment because of severe male infertility.DesignMulticentre,…

2022
Preimplantation genetic testing for aneuploidy in severe male factor infertility: protocol for a multicenter randomised controlled trial.
BMJ open ·doi:10.1136/bmjopen-2022-063030

IntroductionConventional intracytoplasmic sperm injection (ICSI) is a widely used treatment for couples with severe male infertility. However, there are controversies regarding the selection and the damage to gametes during the ICSI procedu…

article 2016
Hyaluronic acid reagent functional chitosan-PEI conjugate with AQP2-siRNA suppressed endometriotic lesion formation
International journal of nanomedicine ·doi:10.2147/ijn.s99692

To identify a new drug candidate for treating endometriosis which has fewer side effects, a new polymeric nanoparticle gene delivery system consisting of polyethylenimine-grafted chitosan oligosaccharide (CSO-PEI) with hyaluronic acid (HA) …

article 2013
The Effect of Peritoneal Fluid from Patients with Endometriosis on Mitochondrial Function and Development of Early Mouse Embryos
PloS one ·doi:10.1371/journal.pone.0082334

BACKGROUND: Peritoneal fluid (PF) from patients with endometriosis can inhibit early embryo development via probable functional changes of embryo mitochondria in the early stage of embryo development. The purpose of this study was to determ…

review 2012
Functions of water channels in male and female reproductive systems
Molecular aspects of medicine ·doi:10.1016/j.mam.2012.02.002

Twelve water channels (aquaporins) are expressed in mammalian reproductive systems, and play very important roles in maintaining water homeostasis in reproductive cells. Impairment of their functions can result in attenuated male and female…

article 2008
17ß-estradiol-induced human endometrial stromal cell invasion is dependent on c-fos-mediated matrix metalloproteinase-9 expression
Fertility and sterility ·doi:10.1016/j.fertnstert.2008.07.949
article 2008
Decreased expression of endometrial vessel AQP1 and endometrial epithelium AQP2 related to anovulatory uterine bleeding in premenopausal women
·doi:10.1097/gme.0b013e31816086ef

OBJECTIVE: Aquaporins (AQPs) may be involved in the occurrence of abnormal uterine bleeding as the mediators between ovarian steroids and cyclic endometrial changes. The aim of the present study was to investigate the characteristics of end…

article 2007
Increased expression of c-fos protein associated with increased matrix metalloproteinase-9 protein expression in the endometrium of endometriotic patients
Fertility and sterility ·doi:10.1016/j.fertnstert.2007.07.1386

ObjectiveTo investigate c-fos and matrix metalloproteinase-9 (MMP-9) expression in the endometrium from women with or without endometriosis throughout the menstrual cycle, and to explore the correlation of c-fos expression with MMP-9 expres…

article 2006
Vascular endothelial growth factor and matrix metalloproteinase-2 expedite formation of endometriosis in the early stage ICR mouse model
Fertility and sterility ·doi:10.1016/j.fertnstert.2005.12.083

ObjectiveTo establish a mouse model for endometriosis and to evaluate roles of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-2 (MMP-2) in the formation of disease.DesignExperimental laboratory study.SettingA women's…

article 2004
Matrix metalloproteinase 2 is associated with changes in steroid hormones in the sera and peritoneal fluid of patients with endometriosis
Fertility and sterility ·doi:10.1016/j.fertnstert.2003.10.027

ObjectiveTo determine matrix metalloproteinase 2 (MMP-2) levels in sera and peritoneal fluids of women with or without endometriosis-associated infertility and to determine whether MMP-2 had correlation with 17beta-E(2) and P in the sera an…

article 2004
The role of VEGF and MMP-2 in the early stage of evolution of endometriosis
·doi:10.1016/j.ics.2004.04.087