Pickles J

No ORCID on file · 2 papers in corpus

observational 2026

Diminished sex hormone levels influence the risk of skewed X chromosome inactivation

·doi:10.64898/2026.04.20.26351303

Background X chromosome inactivation (XCI) is the mechanism which randomly silences one X chromosome to equalise gene expression between 46, XX females and 46, XY males. Though XCI is expected to result in a random pattern of mosaicism acr…

observational 2024

Prevalence of multiple long-term conditions (multimorbidity) in England: a whole population study of over 60 million people

Journal of the Royal Society of Medicine ·doi:10.1177/01410768231206033

OBJECTIVES: To determine the prevalence of multiple long-term conditions (MLTC) at whole English population level, stratifying by age, sex, socioeconomic status and ethnicity. DESIGN: A whole population study. SETTING: Individuals registe…