Leen J. Blok — Endo Lab

review 2011

Interaction between sex hormones and WNT/β-catenin signal transduction in endometrial physiology and disease

·doi:10.1016/j.mce.2011.06.010

Wnt/β-catenin signalling plays a rate-limiting role in early development of many different organs in a broad spectrum of organisms. In the developing Müllerian duct, Wnt/β-catenin signalling is important for initiation, outgrowth, patternin…

article 2009

Progesterone Inhibition of Wnt/β-Catenin Signaling in Normal Endometrium and Endometrial Cancer

·doi:10.1158/1078-0432.ccr-09-0814

PURPOSE: Wnt signaling regulates the fine balance between stemness and differentiation. Here, the role of Wnt signaling to maintain the balance between estrogen-induced proliferation and progesterone-induced differentiation during the menst…

article 2006

Histological and immunohistochemical evaluation of postmenopausal endometrium after 3 weeks of treatment with tibolone, estrogen only, or estrogen plus progestagen

·doi:10.1016/j.fertnstert.2005.12.077

ObjectiveTo evaluate histological and immunohistochemical parameters of short-term (21 days) tibolone, estrogen-only, and estrogen+progestagen treatment in the human postmenopausal endometrium.DesignAn observational, open, nonrandomized, co…