John A. Martignetti

diagnostic-accuracy 2026

From Operating Room to Office: Translational Pathway for a Machine Learning–Driven Uterine Lavage Liquid Biopsy for Endometriosis and Adenomyosis

·doi:10.1097/aog.0000000000006208.1

INTRODUCTION: Endometriosis and adenomyosis are leading causes of chronic pelvic pain and infertility, affecting millions of reproductive-aged women worldwide. Despite their prevalence, diagnostic delays average 8–10 years, driven by relian…

case-report 2018

Detection of endometrial precancer by a targeted gynecologic cancer liquid biopsy

Cold Spring Harbor molecular case studies ·doi:10.1101/mcs.a003269

Endometrial cancer is the most common gynecologic malignancy in industrialized countries, and both its incidence and its associated mortality are increasing. The "liquid biopsy" is becoming an important transformative precision oncology too…

observational 2016

Genomic Analysis of Uterine Lavage Fluid Detects Early Endometrial Cancers and Reveals a Prevalent Landscape of Driver Mutations in Women without Histopathologic Evidence of Cancer: A Prospective Cross-Sectional Study

PLoS medicine ·doi:10.1371/journal.pmed.1002206

BACKGROUND: Endometrial cancer is the most common gynecologic malignancy, and its incidence and associated mortality are increasing. Despite the immediate need to detect these cancers at an earlier stage, there is no effective screening met…

other 2015

Personalized Circulating Tumor DNA Biomarkers Dynamically Predict Treatment Response and Survival In Gynecologic Cancers

PloS one ·doi:10.1371/journal.pone.0145754

BACKGROUND: High-grade serous ovarian and endometrial cancers are the most lethal female reproductive tract malignancies worldwide. In part, failure to treat these two aggressive cancers successfully centers on the fact that while the major…