Wang H

BACKGROUND: Bisphenol A (BPA), a widespread environmental endocrine disruptor, has raised concerns for its neurotoxic effects, yet its molecular role in stroke remains unclear. METHODS: BPA target genes were retrieved from ChEMBL, DrugBank,…

Endometriosis (EMs) and recurrent miscarriage (RM) represent major reproductive health challenges. This study investigates the involvement of endothelial-mesenchymal transition (EndMT) in these conditions through integrative bioinformatics …

BACKGROUND: Diabetic foot ulcers (DFU) are one of the most common and severe complications of diabetes, closely associated with high amputation rates and mortality, and the clinical treatment research is still limited. Previous studies have…

OBJECTIVES: Some previous studies examined the knowledge, attitudes, and practices (KAP) toward prenatal genetic testing of the fetus but not toward blood chromosomal testing in the preconception and premarital period. This study investigat…

Primordial follicles form the non-renewable germline reserve in female mammals; their limited number is a key determinant of reproductive lifespan and is crucial for female fertility. Insufficient or parasomnia sleep is common in females, y…

INTRODUCTION AND HYPOTHESIS: This study is aimed at evaluating the clinical efficacy of matrix radiofrequency combined with myofascial manipulation in the treatment of myofascial pelvic pain (MPP) and to assess its effects on pain relief an…

BACKGROUND: Endometriosis (EMs) is a persistent inflammatory condition whose three main symptoms, mass, pain, and infertility, severely affect female patients of childbearing age. Hu-Po-San (HPS), a preparation consisting of various herbal …

The matrix metalloproteinase (MMP) family includes several membrane-bound enzymes. Membrane-type 5 matrix metalloproteinase (MT5-MMP) is unique amongst the MMP family in being primarily expressed in the brain and during development. It is p…

INTRODUCTION: The aim of the study was to explore the impact of the clinical and embryological factors on the pregnancy outcome of FET cycle, while determining the applicability range for the primary predictor. METHODS: A total of 4395 FET…

BACKGROUND: Although many studies have validated the diagnostic performance of Ovarian-Adnexal Reporting and Data Systems ultrasound (O-‎RADS US), most have been observed by experienced sonologists, and relatively few by junior sonologists.…

INTRODUCTION: Ovarian adenomyoma is a rare gynecological tumor with a high misdiagnosis rate, leading many patients to undergo unnecessary surgeries that may affect fertility. Menstrual abdominal pain is the most common symptom, and auxilia…

Ovarian endometrioma (OEM), a particularly severe form of endometriosis, is an oestrogen-dependent condition often associated with pain and infertility. The mechanisms by which OEM impairs fertility, particularly through its direct impact o…

BACKGROUND: Despite epidemiological studies linking phthalates to ovarian cancer, their multi-target molecular mechanisms remain unresolved, hindering biomarker discovery and preventive strategies. This study integrates network toxicology, …

BACKGROUND: Maternal short-term outcomes of postpartum depression (PPD) were widely examined, but little is known about its long-term association with multiple chronic diseases (multimorbidity) in women's later life. This study aims to asse…

PURPOSE: A retrospective observational study was conducted to investigate the predictors for recurrence of stage I-II endometrial cancer after surgical treatment. METHODS: 130 stage I-II endometrioid carcinoma patients receiving laparoscop…

BACKGROUND: To investigate the optimal periendometrial zone (PEZ) in ultrasound (US) images and assess the performance of ultrasound radiomics in predicting the outcome of frozen embryo transfer (FET). METHODS: This prospective study had 4…

OBJECTIVE: To analyze the relationship and predictive value of Netrin-1 expression and ultrasonic blood flow parameters with the severity of cervical intraepithelial neoplasia (CIN). METHODS: A retrospective analysis was performed on 115 p…

Significant physiological changes occur in both the fetus and the mother during pregnancy. Urine proteins have been shown to reflect a wide range of physiological and pathological changes in the body. This study employed low-abundance prote…

Endometrial fibrosis can lead to uterine infertility. Accurate staging of endometrial fibrosis is crucial for developing treatment plans and performing dynamic follow-ups. This study aimed to evaluate the feasibility of radiomics models bas…

Endothelial-mesenchymal transition (EndMT) is a biological process in which endothelial cells lose intercellular junctions and endothelial characteristics under specific pathophysiological stimuli and acquire mesenchymal traits. It plays a …

Fertility in women decreases with age, but the molecular basis for age-related, unexplained infertility remains elusive. Here, we reveal distinct transcriptome changes in oocytes and surrounding cumulus cells from women in their mid-thirtie…

RAD18 is a crucial mismatch repair gene associated with the post-replication repair, and genetic variations in RAD18 gene are closely related to tumorigenesis. We selected 6 RAD18 SNP and performed mismatch amplification PCR on 650 cases of…

Innate lymphoid cells (ILCs) are a newly discovered subset of immune cells that are responsible for regulation of the immune microenvironment. In particular, the ILC categories ILC2s and regulatory ILCs (ILCregs) are associated with immunos…

INTRODUCTION: Intrauterine adhesions (IUAs) are one of the most common causes of uterine infertility. Hysteroscopic adhesiolysis is the primary treatment for IUA, but the rate of IUA recurrence is high in moderate to severe cases. While tra…

BACKGROUND: Bronchopulmonary dysplasia (BPD) is a common chronic respiratory disease in preterm infants, and its incidence has gradually increased with advances in medical technology. BPD is associated with multiple complications, significa…