Sharp A

No ORCID on file · 3 papers in corpus
2025
Defactinib with avutometinib in patients with solid tumors: the phase 1 FRAME trial.
Nature medicine ·doi:10.1038/s41591-025-03763-y

Use of signal transduction inhibitors as single agents to treat cancer leads to resistance because of the plasticity of intracellular signaling, and combination therapy can overcome this. We describe the first-in-human trial of avutometinib…

2025
The CASPAR study protocol. Can cervical stiffness predict successful vaginal delivery after induction of labour? a feasibility, cohort study.
PloS one ·doi:10.1371/journal.pone.0311324

BackgroundInduction of labour (IOL) is a common obstetric intervention in the UK, affecting up to 33% of deliveries. IOL aims to achieve a vaginal delivery prior to spontaneous onset of labour to prevent harm from ongoing pregnancy complica…

2025
The PRECISION study protocol: Can cervical stiffness in the second trimester predict preterm birth in high-risk singleton pregnancies? A feasibility, cohort study.
PloS one ·doi:10.1371/journal.pone.0316297

BackgroundPreterm birth (PTB) is a leading cause of neonatal morbidity and mortality. More than 13 million babies are affected globally every year and PTB will contribute to over 900,000 deaths. In the UK, PTB affects 8% of pregnancies and …