Bremner Wj

No ORCID on file · 3 papers in corpus
nonrandomized-trial 2009
Oral administration of the GnRH antagonist acyline, in a GIPET-enhanced tablet form, acutely suppresses serum testosterone in normal men: single-dose pharmacokinetics and pharmacodynamics
Cancer chemotherapy and pharmacology ·doi:10.1007/s00280-009-1038-1

PURPOSE: GnRH analogs are useful for the treatment of prostate cancer, but require parenteral administration. The peptide GnRH antagonist acyline potently suppresses luteinizing hormone (LH) and testosterone in man; however, its clinical ut…

review 1996
Androgens in men--uses and abuses
New England Journal of Medicine ·doi:10.1056/NEJM199603143341107
review 1982
Male contraception: clinical trials.

Current research in the chemical and hormonal disruption of the male reproductive system is reviewed. The authors suggest that it is possible to induce azoospermia and oligospermia in 70-100% of normal men. The most promising compounds are …