Smith M

PurposeInfertility affects 1 in 6 couples, yet male fertility assessments often rely on semen analysis alone, which has limited predictive value for treatment success. This study evaluates an epigenetic tool for assessing sperm quality, aim…

Background Given around 50% of people with heart failure have a degree of iron deficiency, guidelines recommend screening. It is uncertain to what extent this is done in primary care and whether testing is equitable. Aim To report the pro…

Aims Iron deficiency is common among people with heart failure and associated with morbidity and mortality. While intravenous iron improves clinical outcomes, oral iron continues to be prescribed in routine practice despite limited evidenc…

BackgroundPremenstrual and menstrual symptoms arise in response to cyclical hormonal fluctuations and encompass psychological and physical manifestations that may significantly impair quality of life. Treatment options are limited, demonstr…

Hormone replacement therapy (HRT) with oestrogen and progestogen is a common medical treatment for alleviating symptoms of menopause. Since 2015, its use has been increasing in the UK. Unscheduled bleeding can be a symptom of endometrial ca…

ContextGenetic variants affecting the nuclear hormone receptor coactivator steroid receptor coactivator, SRC-1, have been identified in people with severe obesity and impair melanocortin signaling in cells and mice. As a result, obese patie…

INTRODUCTION: Endometriosis is a common gynaecological disease associated with pelvic pain and subfertility. There are no non-invasive diagnostic tests, medical management requires suppression of oestrogens and surgical removal is associate…

Cancer antigen 125 (CA 125) is a transmembrane glycoprotein expressed on the surface of germinal epithelium and other tissues derived from embryonic coelomic epithelium (Bischof, 1993). CA 125 is a useful biomarker to detect treatment respo…