Grygielko ET

No ORCID on file · 3 papers in corpus
other 2010
Improving the developability profile of pyrrolidine progesterone receptor partial agonists
Bioorganic & medicinal chemistry letters ·doi:10.1016/j.bmcl.2009.10.092

The previously reported pyrrolidine class of progesterone receptor partial agonists demonstrated excellent potency but suffered from serious liabilities including hERG blockade and high volume of distribution in the rat. The basic pyrrolidi…

article 2009
Estrogen-induced stromal cell-derived factor-1 (SDF-1/Cxcl12) expression is repressed by progesterone and by Selective Estrogen Receptor Modulators via estrogen receptor α in rat uterine cells and tissues
Steroids ·doi:10.1016/j.steroids.2009.07.011

Endometriosis, defined as the presence of endometrial glands and stroma at extra-uterine sites, is a gynecological condition that affects women of reproductive age. Consistent with its uterine origins, endometriotic lesions and resulting sy…

other 2007
A structural and in vitro characterization of asoprisnil: a selective progesterone receptor modulator
Molecular Endocrinology ·doi:10.1210/me.2006-0524

Selective progesterone receptor modulators (SPRMs) have been suggested as therapeutic agents for treatment of gynecological disorders. One such SPRM, asoprisnil, was recently in clinical trials for treatment of uterine fibroids and endometr…