Seiichi Tamai

No ORCID on file · 11 papers in corpus · active 1996-2012

Study types

  • other 7
  • article 3
  • review 1

Condition tags

  • endometriosis 11
other 2012
Accumulative copy number increase of MET drives tumor development and histological progression in a subset of ovarian clear-cell adenocarcinomas
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc ·doi:10.1038/modpathol.2011.143

Our previous study demonstrated that, among ovarian carcinomas, amplification of the MET gene and overexpression of MET specifically and commonly occur in clear-cell adenocarcinoma histology. This study was conducted to address how these al…

other 2012
ACTN4 gene amplification and actinin-4 protein overexpression drive tumour development and histological progression in a high-grade subset of ovarian clear-cell adenocarcinomas
Histopathology ·doi:10.1111/j.1365-2559.2011.04163.x

AIMS: Actinin-4, encoded by the ACTN4 gene located on chromosome 19q13.2, enhances cell motility by bundling the actin cytoskeleton. We assessed how ACTN4/actinin-4 alterations contribute to the tumorigenesis of ovarian clear-cell adenocarc…

other 2012
Loss of ARID1A protein expression occurs as an early event in ovarian clear-cell carcinoma development and frequently coexists with PIK3CA mutations
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc ·doi:10.1038/modpathol.2011.189

ARID1A is a recently identified tumor suppressor gene that is mutated in ∼50% of ovarian clear-cell carcinomas. This mutation is associated with loss of ARID1A protein expression as assessed by immunohistochemistry. The present study aimed …

other 2012
PIK3CA mutations and loss of ARID1A protein expression are early events in the development of cystic ovarian clear cell adenocarcinoma
Virchows Archiv : an international journal of pathology ·doi:10.1007/s00428-011-1169-8

Somatic mutations of PIK3CA and ARID1A are the most common genetic alterations observed in ovarian clear cell adenocarcinomas (CCA). In a previous report, we showed that PIK3CA gene mutations and loss of ARID1A expression occur early during…

article 2011
PIK3CA mutation is an early event in the development of endometriosis‐associated ovarian clear cell adenocarcinoma
The Journal of Pathology ·doi:10.1002/path.2940

Clear cell adenocarcinoma (CCA), a highly lethal histological subtype of ovarian carcinoma, is a type of human cancer with a high frequency of activating mutations in the PIK3CA gene. In this study, we aimed to determine how these mutations…

article 2010
Cumulative alterations of p27Kip1‐related cell‐cycle regulators in the development of endometriosis‐associated ovarian clear cell adenocarcinoma
Histopathology ·doi:10.1111/j.1365-2559.2010.03551.x

AIMS: To identify the key cell-cycle dysregulations in the development of endometriosis-associated ovarian clear cell adenocarcinoma (CCA). METHODS AND RESULTS: Expression of p27(Kip1)-interacting cell-cycle regulators, such as p27(Kip1) it…

other 2009
Aberrant expression of p27(Kip1)-interacting cell-cycle regulatory proteins in ovarian clear cell carcinomas and their precursors with special consideration of two distinct multistage clear cell carcinogenetic pathways
Virchows Archiv : an international journal of pathology ·doi:10.1007/s00428-009-0844-5

We have previously reported that alterations of p27(Kip1)-interacting cell-cycle proteins frequently occur during the development of endometriosis-associated ovarian clear cell adenocarcinoma (CCA; Yamamoto et al., Histopathology in press, …

article 2009
An allelotype analysis indicating the presence of two distinct ovarian clear-cell carcinogenic pathways: endometriosis-associated pathway vs. clear-cell adenofibroma-associated pathway
Virchows Archiv : an international journal of pathology ·doi:10.1007/s00428-009-0816-9
other 2008
Expression of platelet-derived growth factors and their receptors in ovarian clear-cell carcinoma and its putative precursors
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc ·doi:10.1038/modpathol.3800984

Recent studies have shown that platelet-derived growth factors and their receptors are frequently co-expressed in ovarian cancers. Herein, we investigated the role of the platelet-derived growth factor pathway in the development of ovarian …

other 2007
Clear cell adenocarcinoma associated with clear cell adenofibromatous components: a subgroup of ovarian clear cell adenocarcinoma with distinct clinicopathologic characteristics
The American journal of surgical pathology ·doi:10.1097/01.pas.0000249449.13466.3c

We occasionally encountered clear cell adenofibromatous (CCAF) components coexisting in the ovarian clear cell adenocarcinoma (CCA). To reveal the clinicopathologic significance of CCAF components in CCA, we classified 67 cases of surgicall…

review 1996
Spontaneous rupture of the uterine vessels in a pregnancy complicated by endometriosis
Acta obstetricia et gynecologica Scandinavica ·doi:10.3109/00016349609054718

(1996). Spontaneous rupture of the uterine vessels in a pregnancy complicated by endometriosis. Acta Obstetricia et Gynecologica Scandinavica: Vol. 75, No. 9, pp. 860-862.