Beranič N

No ORCID on file · 4 papers in corpus
article 2012
Effects of progestins on local estradiol biosynthesis and action in the Z-12 endometriotic epithelial cell line
The Journal of steroid biochemistry and molecular biology ·doi:10.1016/j.jsbmb.2012.07.004

Endometriosis is a common estrogen-dependent gynecological disease. In patients with endometriosis estradiol can be synthesized locally in the endometriotic lesions from inactive precursors of adrenal or ovarian origin, via the aromatase pa…

article 2012
Expression of human aldo-keto reductase 1C2 in cell lines of peritoneal endometriosis: Potential implications in metabolism of progesterone and dydrogesterone and inhibition by progestins
The Journal of steroid biochemistry and molecular biology ·doi:10.1016/j.jsbmb.2011.12.011

The human aldo-keto reductase AKR1C2 converts 5α-dihydrotestosterone to the less active 3α-androstanediol and has a minor 20-ketosteroid reductase activity that metabolises progesterone to 20α-hydroxyprogesterone. AKR1C2 is expressed in dif…

article 2012
Progestin effects on expression of AKR1C1–AKR1C3, SRD5A1 and PGR in the Z-12 endometriotic epithelial cell line
Chemico-biological interactions ·doi:10.1016/j.cbi.2012.10.028

Endometriosis is defined as the presence of endometrial glands and stroma outside the uterine cavity. This disease is associated with diminished protective effects of progesterone, which are usually explained by inadequate activation of pro…

other 2011
Progestins as inhibitors of the human 20-ketosteroid reductases, AKR1C1 and AKR1C3
Chemico-biological interactions ·doi:10.1016/j.cbi.2010.12.012

The human aldo-keto reductases 1C1 and 1C3 (AKR1C1 and AKR1C3) are important 20-ketosteroid reductases in pre-receptor regulation of progesterone action. Both AKR1C1 and AKR1C3 convert progesterone to the less potent metabolite 20α-hydroxyp…