Leonardo Jacobsen

No ORCID on file · 3 papers in corpus
review 2026
Peritoneal Incretin Deficiency and Tirzepatide as a Multi-Axis Adjuvant Hypothesis in Treatment-Refractory Endometriosis: A Mechanistic Framework Linking Metabolism, Immunity, Fibrosis, and Nociception
International journal of molecular sciences ·doi:10.3390/ijms27135678

Endometriosis is increasingly recognized as a chronic systemic disorder extending beyond the classical estrogen-dependent paradigm, integrating metabolic, immune, fibrotic, and nociceptive pathways that sustain lesion persistence and refrac…

preprint 2025
Beyond Efficacy: Tolerability Profiles and Shared Decision-Making in Hormonal Management of Endometriosis-Associated Pain
·doi:10.20944/preprints202508.1818.v1

Background: The management of endometriosis-associated pain has traditionally focused on analgesic efficacy. However, with high-level evidence demonstrating therapeutic equivalence among principal hormonal classes, the paradigm has shifted …

review 2025
Tolerability and Shared Decision-Making in the Hormonal Management of Endometriosis-Associated Pain
Biomedicines ·doi:10.3390/biomedicines13092294

Background: The management of endometriosis-associated pain has traditionally focused on analgesic efficacy. However, with high-level evidence demonstrating therapeutic equivalence among principal hormonal classes, the paradigm has shifted …