Grimshaw JM

ORCID: 0000-0001-8015-8243 · 1 paper in corpus

2013

Threats to validity in the design and conduct of preclinical efficacy studies: a systematic review of guidelines for in vivo animal experiments.

PLoS medicine ·doi:10.1371/journal.pmed.1001489

BackgroundThe vast majority of medical interventions introduced into clinical development prove unsafe or ineffective. One prominent explanation for the dismal success rate is flawed preclinical research. We conducted a systematic review of…