Colin O. Wu

Introduction: Telomere biology disorders (TBDs) are characterized by abnormal telomere maintenance and a clinically heterogenous phenotype, including marrow failure, pulmonary fibrosis, cirrhosis, and malignancy predisposition. Treatment op…

BACKGROUND: Genetic defects in telomere maintenance and repair cause bone marrow failure, liver cirrhosis, and pulmonary fibrosis, and they increase susceptibility to cancer. Historically, androgens have been useful as treatment for marrow …