Salama SA
No ORCID on file
· 3 papers in corpus
Ulipristal acetate (UPA) is effective in the treatment of uterine fibroids. However, its clinical use is hampered by the development of pathologic progesterone receptor modulator-associated endometrial changes (PAECs). The current study was…
CONTEXT: Estrogen and its metabolites play a critical role in the pathophysiology of the endometrium. The bioavailability of estrogen and estrogen metabolites in endometrial tissues depends on the expression of enzymes involved in estrogen …
OBJECTIVE: To investigate the role of catechol-O-methyl transferase (COMT) in the regulation of estrogen metabolism in human endometrium. DESIGN: Laboratory study. SETTING: Academic research laboratory. INTERVENTION(S): Immunohistochemis…